Warren Releases Results of DNA Test

Senator Elizabeth Warren has released a DNA test that provides “strong evidence’’ she had a Native American in her family tree dating back 6 to 10 generations, an unprecedented move by one of the top possible contenders for the 2020 Democratic nomination for president.

Warren, whose claims to Native American blood have been mocked by President Trump and other Republicans, provided the test results to the Globe on Sunday in an effort to defuse questions about her ancestry that have persisted for years. {snip}

The analysis of Warren’s DNA was done by Carlos D. Bustamante, a Stanford University professor and expert in the field who won a 2010 MacArthur fellowship, also known as a genius grant, for his work on tracking population migration via DNA analysis.

He concluded that “the vast majority” of Warren’s ancestry is European, but he added that “the results strongly support the existence of an unadmixed Native American ancestor.”

Bustamante calculated that Warren’s pure Native American ancestor appears in her family tree “in the range of 6-10 generations ago.” That timing fits Warren’s family lore, passed down during her Oklahoma upbringing, that her great-great-great-grandmother, O.C. Sarah Smith, was at least partially Native American.

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The inherent imprecision of the six-page DNA analysis could provide fodder for Warren’s critics. If O.C. Sarah Smith were fully Native American, that would make Warren up to 1/32nd native. But the generational range based on the ancestor that the report identified suggests she’s between 1/64th and 1/1,024th Native American. The report notes there could be missed ancestors.

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The move is also another indication of how seriously Warren is considering running for president. And while it’s unclear whether the test will convince Trump and his die-hard supporters, Warren will be able to point to it with other, more open-minded voters. {snip}

Warren is seeking reelection in Massachusetts and is expected to easily win a second term. She has said that she will take a “hard look” at running for the Democratic nomination for president once the midterm elections are over. She’s already released 10 years worth of her tax returns and made her personnel files available to The Boston Globe, showing that ethnicity was not a factor in her rise in law.

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Warren provided a sample of her DNA to a private lab in Georgia in August, according to one of the senator’s aides. The data from that test was sent to Bustamante and his team for analysis. Warren received the report last week.

Warren didn’t use a commercial service, but Bustamante is on the scientific advisory board for Ancestry, which provides commercial DNA tests. He’s also consulted on a project for 23andMe, another major DNA testing company.

Warren said she was committed to releasing the report regardless of the results. However, Warren’s aides would not say whether she or any of her three siblings had previously done a commercial DNA test that would have provided them with some assurance about Bustamante’s analysis.

There were five parts of Warren’s DNA that signaled she had a Native American ancestor, according to the report. The largest piece of Native American DNA was found on her 10th chromosome, according to the report. Each human has 23 pairs of chromosomes.

“It really stood out,” said Bustamante in an interview. “We found five segments, and that long segment was pretty significant. It tells us about one ancestor, and we can’t rule out more ancestors.”

He added: “We are confident it is not an error.”

Detecting DNA for Native Americans is particularly tricky because there is an absence of Native American DNA available for comparison. This is in part because Native American leaders have asked tribal members not to participate in genetic databases.

“The tribes have felt they have been exploited,” explained Lawrence Brody, a senior investigator with the Medical Genomics and Metabolic Genetics Branch at the National Institutes of Health. “The amount of genetic data that is available from Native Americans is sparse.”

To make up for the dearth of Native American DNA, Bustamante used samples from Mexico, Peru, and Colombia to stand in for Native American. That’s because scientists believe that the groups Americans refer to as Native American came to this land via the Bering Straight about 12,000 years ago and settled in what’s now America but also migrated further south. His report explained that the use of reference populations whose genetic material has been fully sequenced was designed “for maximal accuracy.”

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Bustamante also compared Warren’s DNA to white populations in Utah and Great Britain to determine if the amounts of Native American markers in Warren’s sample were significant or just background noise.

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He also offered to provide $1 million to her charity of choice if she takes the test.

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Bustamante is considered one of the leading DNA analysts in the world. When several DNA experts were asked by the Globe, earlier this year, how they’d recommend Warren go about taking a DNA test, his name came up repeatedly.

He has never donated to Warren’s campaigns. (A different California professor with the same name donated $200 to Obama in 2008, federal records show.)

Questions over Warren’s ethnicity have dogged her since her 2012 Senate campaign. That’s when GOP operatives found archival stories in the Harvard Crimson of a Harvard Law School spokesman referring to her as a Native American as a way to show the school had a diverse faculty.

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