Gene That Once Aided Survival in the Arctic Found to Have Negative Impact on Health Today

Medical Xpress, October 23, 2014

In individuals living in the Arctic, researchers have discovered a gene variant that arose thousands of years ago and most likely provided an evolutionary advantage for processing high-fat diets or for surviving in a cold environment; however, the variant also seems to increase the risk of hypoglycemia, or low blood sugar, and infant mortality in today’s northern populations. {snip}

“Our work describes a case where the same variant has likely been selectively advantageous in the past [but] disadvantageous under current environmental conditions,” says senior author Dr. Toomas Kivisild, of the University of Cambridge, in the UK.

Dr. Kivisild and his colleagues analyzed the genomes of 25 individuals from Northern Siberia and compared their sequences with those from 25 people from Europe and 11 from East Asia. The team identified a variant that was unique to Northern Siberians and was located within CPT1A, a gene that encodes an enzyme involved in the digestion of long fatty acids, which are prevalent in meat-based diets. {snip}

When the investigators looked at the global distribution of the CPT1A variant, they found that it was present in 68% of individuals in the Northern Siberian population yet absent in other publicly available genomes. The variant has previously been linked to high infant mortality and hypoglycemia in Canadian Inuits, and its high frequency in these populations has been described as a paradox.

{snip}

Topics: , ,

Share This

We welcome comments that add information or perspective, and we encourage polite debate. If you log in with a social media account, your comment should appear immediately. If you prefer to remain anonymous, you may comment as a guest, using a name and an e-mail address of convenience. Your comment will be moderated.
  • Oil Can Harry

    This study is racist trash.

    After all, race is a social construct so it’s impossible that different ethnic groups should have different immune systems.

    And by the way, you bigoted scientists, BLACK LIVES MATTER!

    • propagandaoftruth

      Is this saying that the ability to build up insulating, sustaining, fat layers – useful in a frozen world of scarcity – might be bad in a warm world of plenty?

      Duh…

      Huh?

      • Not quite. Race works, except when it doesn’t, or something like that, unless otherwise contra-indicated.

    • SpiritSplice

      Is this trolling?

  • haroldcrews

    Hypoglycemia isn’t a problem so long as your diet is primarily fat. My diet is 75% or 80% saturated and monosaturated fat and my glucose levels stay in the 60’s and 70’s without adverse effects. Ketogenic diets have numerous beneficial health consequences. Those benefits are not limited to just those having an Arctic ancestry either.

    • SoulInvictus

      Same here. Mostly Paleo eating for the past year+ and I am by far healthier, stronger, and more youthful than people I meet that are 10 years younger.
      Hi carb/low fat/fat is the devil diet is another fraud promoted by the government backed by no science.

      • Garrett Brown

        To make white men weak and pathetic with no sex drive.

        • SoulInvictus

          Yeah, don’t even get me started on estrogen mimics in plastics and all the other chemical garbage (especially in “vegetarian/vegan” products).
          Half of white America trying to actually be healthy and while doing something as simple as drinking bottled water instead of soda’s…and then not knowing they’re driving the girls into puberty earlier and the boys into manboobness.
          I know it isn’t exactly party line for views on this site, but they do it to everyone… the toxic level of vaccine garbage they shoot into kids is really bad on boys, but roughly twice as bad on black boys.
          CDC doctors have come out lately saying it’s absolutely responsible for the spike in autism… yet no change in vaccine policy for children.

          Because what we definitely need is an even more dumbed down, even more semi retarded and violent population of those…
          but great for perpetuating a permanent underclass to prey on.

          • Garrett Brown

            I thought the CDC clearly stated vaccines were NOT the cause of mental defects?

          • SoulInvictus

            Oh, the CDC itself has never backed down on pumping loads of successive vaccines into small children…when even vets don’t advise that for animals.
            But…
            “Beyond admitting to fraud in a 2004 CDC study that exonerated the MMR (Measles Mumps Rubella)
            vaccine, Dr. William Thompson, a CDC scientist, asserts there is a
            connection between mercury (thimerosal) in vaccines and autism…
            Thompson states that giving a vaccine containing mercury to a pregnant woman is something he would never do…Thompson winds up his remarks with this:
            “There is biologic plausibility right now to say thimerosal causes
            autism-like features.”

            http://wwwDOTinfowarsDOTcom/bombshell-cdc-whistleblower-goes-further-mercury-causes-autism/

            The video interview with him is even more damning than those quotes.

      • SpiritSplice

        Same is true of low carb. Humans need balance.

  • JohnEngelman

    Genetic characteristics that were beneficial in the past are often dysfunctional in the present. Before civilization physically aggressive men were likely to have more descendants. Since civilization began they have been more likely to be executed or imprisoned by criminal justice systems. That is why races that have practiced civilization for several thousand years have lower crime rates than races that have been recently introduced.

    • humura

      But in the US and Europe today, we no longer execute the aggressive and the murderers. The genes that helped us build civilization, allowed us to assume an end to aggression among those incorporated into the nation. Those genetic traits are now counter-productive, for those with a more barbarous character now have the advantage.

    • Physically aggressive men, up to a point. Remember that bears and sharks can always cull the stupid hunters and fishers. A band of guys hunting mammoths for food or that annoying sabretooth which had picked off someone’s kid for the last time would want their brothers and all of their friends along.

      It also takes intelligence.

      • JohnEngelman

        Physical aggression is usually a liability in a professional environment. Imagine what would happen to an engineer who got angry at another engineer in a business meeting, and challenged him to go out into the parking lot to fight it out.

    • SpiritSplice

      High Tech societies also allow for pathological ideologies like Feminism and socialism to run rampant.

      • JohnEngelman

        How are those ideologies pathological?

        High tech societies outperform low tech societies economically and militarily.

        Feminism is beneficial when it opens opportunities for women who can adequately perform in those opportunities. It is dysfunctional when it pushes women into roles they are not suited for, like combat.

        Social democracy works well in countries where everyone is white. Unfortunately, most Social Democrats do not understand that blacks and Muslims game the system.

        • SpiritSplice

          “How are those ideologies pathological?”

          Because they deny human nature and assume slavery is legitimate.

          “High tech societies outperform low tech societies economically and militarily.”

          Until they implode, yes.

          “Feminism is beneficial when it opens opportunities for women who can adequately perform in those opportunities.”

          Feminism has nothing to do with opening opportunities. Feminism is Cultural Marxism and is about tearing down society by making it self destructive.

          “Social democracy works well in countries where everyone is white.”

          Even if it did, it still isn’t just, on either account. This type of welfare mentality is what led to them ceasing to be white.

          “Unfortunately, most Social Democrats do not understand that blacks and Muslims game the system.”

          I don’t think they care if they do. They see whites are evil, so anything non whites do is justified. I just wish the non whites would target liberals more often.

          • JohnEngelman

            Advocates of democratic socialism think capitalism is more similar to slavery. Feminists think male supremacy is more similar to slavery.

            No high tech society has imploded. High tech is the future, just as during the eighteenth century industrialism was the future.

            Cultural Marxism is a myth. It is a derogatory term for social liberalism.

            Social Democrats do not think whites are evil. Unfortunately, they think blacks and Arabs are intrinsically equal to whites.

            Your opinions seem to be motivated by the need to hate, and by the need to explain what you do not like in terms of a simplistic demonology.

          • SpiritSplice

            “Advocates of democratic socialism think capitalism is more similar to
            slavery. Feminists think male supremacy is more similar to slavery.”

            Because both groups stem from an entitlement mentality that seeks to dominate others to fulfill their own desires.

            “”No high tech society has imploded.”

            I am, of course, speaking relatively. In Roman times, they were high tech, and they destroyed themselves by denying reality, just as modern societies are crumbling for the same reasons.

            “Cultural Marxism is a myth.”

            Not sure how an admitted plan that was outlined and then fulfilled is a myth. You seem to be objecting to terminology here.

            “Social Democrats do not think whites are evil.”

            You must be new to this century/planet. We constantly hear about how whites are inherently racist, that only whites can be racist, that whites are forever guilty for all the evils of the past, evils that we are told are uniquely white, that only whites cannot organize for group interests, that we all have “white privilege”, that whites have no culture of their own, only that which they steal from others. Your assertion is nonsense.

            “Your opinions seem to be motivated by the need to hate”

            Right from the leftist textbook on debating. Whenever someone disagrees, it means they hate.

            “the need to explain what you do not like in terms of a simplistic demonology.”

            I can explain what I do not like in as much depth as is required. How about you stop making assumptions about where I am coming from?

  • dd121

    My advice to Eskimos: stay north.

    • Pathfinder75

      I have some advice of my own to offer to the various peoples of the world:

      To Africans: stay East!
      To Mexicans and Central Americans: stay South!
      To (Asian) Indians,Bangladeshis,Nepalese,etc.: stay West!
      To Muslims: drown yourselves in a bathtub filled with camel urine!

  • PlumberofNazareth

    It’d be interesting to see whether the Dorset had this same adaptation. If not, that could be one of the reasons why they were essentially eliminated by the Inuit.

  • Jim Stiles

    Hypoglycemia beats hyperglycemia any day of the week.

    • SpiritSplice

      Maybe if you are obese and don’t move much.