‘Genome Editing’ Could Correct Genetic Mutations for Future Generations

Medical Xpress, December 15, 2014

Scientists at Indiana University and colleagues at Stanford and the University of Texas have demonstrated a technique for “editing” the genome in sperm-producing adult stem cells, a result with powerful potential for basic research and for gene therapy.

The researchers completed a “proof of concept” experiment in which they created a break in the DNA strands of a mutant gene in mouse cells, then repaired the DNA through a process called homologous recombination, replacing flawed segments with correct ones.

The study involved spermatogonial stem cells, which are the foundation for the production of sperm and are the only adult stem cells that contribute genetic information to the next generation. Repairing flaws in the cells could thus prevent mutations from being passed to future generations.

“We showed a way to introduce genetic material into spermatogonial stem cells that was greatly improved from what had been previously demonstrated,” said Christina Dann, associate scientist in the Department of Chemistry at IU Bloomington and a co-author of the study. “This technique corrects the mutation, theoretically leaving no other mark on the genome.”

The paper, “Genome Editing in Mouse Spermatogonial Stem/Progenitor Cells Using Engineered Nucleases,” was published in the online science journal PLOS-ONE.

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{snip} The researchers used specially designed enzymes, called zinc finger nucleases and transcription activator-like effector nucleases, to create a double strand break in the DNA and bring about the repair of the gene.

Stem cells that had been modified in the lab were then transplanted into the testes of sterile mice. The transplanted cells grew or colonized within the mouse testes, indicating the stem cells were viable. However, attempts to breed the mice were not successful.

“Whether the failure to produce sperm was a result of abnormalities in the transplanted cells or the recipient testes was unclear,” the researchers write.

In a separate study, published this month in the journal Cell Research, scientists from several institutions in China used a different technology to edit a faulty gene in spermatogonial stem cells of mice. In this study, the mice were able to successfully reproduce following transplantation of the cells carrying the corrected gene.

The research developments could open doors for better understanding of stem cells and advances in gene therapy. The ability to edit the genome could facilitate analysis of gene function and the processes by which sperm cells divide and differentiate. The techniques could be used, for instance, to test the functional importance of a genetic mutation implicated in reproductive failure.

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  • David Ashton

    “Eugenics” must be evil, since we want to maximize the number of criminals, cripples and cretins, and produce as much personal and social misery as possible, generation after generation, don’t we?

    • Reynardine

      What do you think welfare is for?

      • David Ashton

        See Kenner.

      • Raymond Kidwell

        Welfare is to dumb down the goyim so that they can be better enslaved. Massive immigration of third worlders- the same. Policy makers are well aware of the effects and it would be possible to help people without, for instance, encouraging single parent households, or encouraging the dumb to breed, but they won’t do that. Rest assured almost all Jewish communities have “genetic counseling” as a requirement and aren’t participating in the dysgenics they push on everyone else. Kind of similar to how they don’t accept all the other beliefs they force feed the rest of us.

    • Kenner

      How would the do-gooders get their endorphin fix? Outside of Africa, that is.

      • David Ashton

        See Reynardine.

      • Raymond Kidwell

        They will probably put something in the water that makes people dumb and gives them health problems, then they can rush in and “save” these people with a bag full of canned goods on the holidays… er wait they already put flouride in the water. Well I guess they will probably just hire someone to break someone’s legs and then they can feel really good about themselves when they pay 10% of the hospital bill. Remember a lot of people think emotionally and not logically, so don’t try to understand this using logic.

    • Raymond Kidwell

      This is something really weird I have noticed in American culture. Almost everyone considers themselves a loser. Most people have a very weak mindset. They are scared of ever being compared to someone else or taking a standardized test or being in any kind of competition because they feel like they will not be good enough. You may think that half the people are winners and half losers but it seems more like 80% of the population has this “why try we’ll just fail anyway” and “the greatest evil in the world is if someone judges me”. It seems the same with white supremacists on the web, which really shocked me. They seem to talk a lot about eugenics and being superior to everyone else but whenever I have talked to them about real action they start crying “why try we’ll just fail” etc. with only a few exceptions.

      But that is the mentality behind the eugenics is evil cult. They feel like they are losers and their friends, family etc. are all losers and have an inferiority complex so they think if anyone actually judged them they wouldn’t be found good enough and be sent to the gas chamber. They aren’t motivated by any concern for society or ideological concern. I mean they don’t hate eugenics because they feel it is inherently bad. They hate it solely on an emotional reason that they themselves feel like they would personally be harmed by it in that they would be judged as useless.

      This really shocks me because most of these people could really be productive and acomplish a lot if they would just get rid of this learned helplessness. I don’t know what it is about the culture that encourages people to be losers. Even relatively smart and strong people mope around acting really docile and scared of their own shadow. Maybe its the drugs or brainwashing or something. It’s just totally irrational. But Christianity encourages this slave mentality, cultural Marxism encourages it, it’s almost as if to be an American or a Christian you must be a loser also. It kind of contradicts what I was always told about America being number one.

      If people just suddenly changed their mindset to a winner mentality they would also radically change their ideology in many ways.

      • David Ashton

        This is a disturbingly perceptive and succinct analysis. The “get up and go” competitive spirit previously associated with White America seems sadly diminished, although money still seems to be a prime measure of human quality. Is it fear of possible failure, or guilt at possible success? “Men like gods” (e.g. transhumanism) may be Satanic impertinence, but “men like wimps” is a Satanic paralysis.

        Nietzsche saw this coming.

        • LHathaway

          Freud. Loss of sex drive. On some level there sets in a lack of hope or confidence of being able to develop a relationship with and score with the babe you want. Exposure to hot babes on TV constantly paired up with average looking male co-star breeds woefully, woefully mismatched babe expectations that can only be fulfilled for a small few.I’m going with that. Something about losers. Who knows? Let’s call this a triangle of possibilities.

          • David Ashton

            I know the USA only second-hand from TV, cinema, reading and friends, so to speak, but haven’t you long had a problem of Jocks with cocks v nerds without birds? Psycho-analysis is largely fraudulent, but how does it make American males losers generally? “Feminism” and porn haven’t helped.

            We must still work for a renaissance, especially among our youth, not wreckage through drugs and propaganda, but clear minds, “bodies of whipcord and nerves of steel”.

          • LHathaway

            “haven’t you long had a problem of Jocks with cocks v nerds without birds?”
            I don’t understand this sentence. As for what else you’ve said, well, the cult following Freud would suggest that mental problems, such as depression or lack or motivation (most personality problems actually) at their root sexual in nature, at least oftentimes. Freud felt homosexuality was a huge burden on the unconscious mind of those afflicted. Freud felt the human mind was neutral towards sexuality, that the preferred sexual partner and the preferred sexual act were something learned. In his own time he never-the-less could have been said to favor heterosexuality over it’s opposite.

          • David Ashton

            The muscular sportsmen rather than the weedy intellectuals get the best looking girls (except in those movies where the roles are reversed).

          • Raymond Kidwell

            The biggest cause of the loser mentality is that losers tend to have the most babies. It’s not the jocks or nerds that are popping out the next generation. It’s the ugly, fat, stupid, rude, drug addict welfare mom who gets a bigger check for every baby she’ll pop out. She’ll sleep with anyone willing to go with her ugly *** and this is also where a lot of mixed race babies come from. Even relatively healthy bloodlines end up crossing with these sub-par ones in various ways. Thus we have so many people that are weak, stupid, weak willed etc. from birth. Another phenonemon that Charles Murray points out is that there is greater stratification. So a lot of the people that are winners end up leaving “public life” and moving into some elite network, living in a gated community etc. and not associating with normal people. So if you are in public (like the internet) you tend to not see many of the winners types who have increasingly needed to be part of a private society.

            But that is not even the full story. This welfare policy is done on purpose as part of a “dumbing down” process but the dumbing down comes from school and media as well.

            I think the loser mentality is mostly the result of psychological warfare. Cultural Marxism’s number one battleground is in the classroom. This is where they do a number of things very covertly. For one they create “learned helplessness” by setting people up for failure. A lot of workplaces do this. They try to instill into you that you deserve the abuse, low wages, exploitation etc. that you receive.

            Another thing is they tell you that you can never know the truth. You must have a sense of collectivism and worship of authority. If you say “Two plus two equals four because I reasoned this out myself and I can demonstrate it through a simple test of physically putting two blocks together” that is a D minus paper.

            “Two plus two equals five (Bernstein and Hensley, 2008). As such we should round up non communists and put them in prison camps (author and wallowitz, 2010), while killing our own parents and making them into chili and eating them (goldsmith, 1999).” The emphasis has gone away from thinking and reasoning and towards group consensus and following authority. People are naturally trained in “obedience school” i.e. public education today to be followers, to feel that their self worth comes from the acceptance of an authority figure and so forth. The elite typically don’t get this kind of schooling. They are taught to be leaders, but such elite people generally aren’t going to assocaite with normal people because they believe they are better than everyone else. So the typical average person has been increasingly trained to be a submissive slave. Christianity also enforces this “be ye slaves” is a real biblical quote I hear churches preaching, as well as obey authority, put your trust in authority (or God) and so forth. Anything other than taking reponsibility for yourself or feeling that you even can solve a problem yourself. “You aren’t able to handle your own problems, let the government solve it” -secular Marxism “You aren’t able to handle your own problems, let God and the church solve it. Just sit back and do what you are told”. -mainstream religion. It’s the same message coming from all directions.

            The third attack are female hormones put in the food and water. This makes people naturally more submissive and less assertive, less confident in themselves, more dependent on the group to make decisions. Then flouride and other chemicals make people dumb, sick, weak etc. to further their submission.

            There is a complete program through breeding, education and drugging made to create wimpy followers who will gladly accept low wages, abuse, eroding rights, Supremacism of the elites etc.

            And now they import massive hoardes of dumb third worlders to further the process. Soon they will be working on population control in lowering the numbers of regular people. Well they already have but it will be stepped up.

            They don’t want a folkish state where most people are the same whether from the lower economic class or the top. They want supremacism where a small elite live this life of privilege at the expense of everyone else. A lot of wealthy people could not compete on their own. They are rich because they inherited what they have or part of the right networks. They don’t want to compete with smart and capable peasants. They also want to keep paying low wages and exploiting people and don’t want to deal with having their head chopped off, or people forming labor unions or striking. They also don’t want people questioning Zionism and Jewish Supremacist activities. They need to dumb them down and batter them into submission.

            Have you ever wondered why people aren’t rioting in the streets at things that would have caused massive riots 50 or 100 years ago? This is done on purpose. They are taming the cattle. Soon they will be wiping out half our population and few people will mutter a word of resistance to it.

          • David Ashton

            Some people will AUTOMATICALLY dismiss this as conspiranoia, but I think much of it is thoughtful and justifiable. The answer is?

          • andyrwebman

            I suppose the question is – where is he right, and where is he wrong? It’s very easy to see correlations where it’s just chance, but on the other hand bits of it do indeed make sense.

          • LHathaway

            You have a point discussing this loser mentality. I think the first time I read about it, heard it put into words, was Dinesh D’Souza in his book ‘illiberal education’ where he wrote, “everyone reaches for the lowest rung of the ladder”. But I remember earlier, when I was a child in 6th or 7th grade or so. My parent gave us kids some helpful advice and I responded to it by saying something like, “You know, in reality playing by the rules will make you unpopular”. My sibling really agreed with this idea. I’d put something into words that was a feeling he shared too (I assume the words I used then, when I spoke to my parent, actually made a fair amount of sense at the time). I remember reading a line in a short story titled something like ‘Greasy Lake’, the writer used a line like, “a time when it was good to be bad”.
            I think you do have a point. Right now, victims are noble, long-suffering, defiant, brave, ‘moral’. I could foresee a time, not so far in the future, when being a victim will just mean you’re a loser. I imagine you’ll be OK with that.

          • Raymond Kidwell

            I’m a victim all the time. I don’t think a victim and a loser are the same thing. Also losing itself is not bad. Losers are really afraid of losing so don’t even try. If someone attacks you and you fight back and you lose the fight, I consider you to be a strong person. If someone attacks you and you just bend over and say “why try I’ll just fail” that would be the type of loser mentality I’m talking about. Self defeatism I guess would be another word for it. It’s not about intelligence either, it’s just about attitude.

          • Reynardine

            Read Twain’s “A Connecticut Yankee in King Arthur’s Court” or Jules Verne’s “The Mysterious Island.” Or any of Jefferson’s stuff, really.

            Intelligence among the early Americans has been considered a strong manly virtue equal to that of fortitude, if not superior. This in turn goes back to the Virtus of the Romans and the Arete of the Greeks: the Indo European “excellence in everything.”

            The divorce between intellect and body is a recent and modern invention that has little grounding in reality. I think the “wussy nerd” is a Jewish projection of themselves onto the media that is their manufactured mythology.

          • Reynardine

            I wouldn’t say Freud really developed that. He just jewed it up real good and made it unpalatable to the western mind. It’s been known at least in the East for millennia that excess sexual activity to completion saps the spiritual strength of man.

            The concepts of cultivating prana and kundalini through meditative celibacy in order to be more active are common themes in Vedic Hindu yoga. They are to be rigorously developed products of the celibate brahmacharya stage in Indian life, which unfortunately no longer is practised there.

            In Chinese understanding as well, qi and qi gong are to be preserved as a man, especially by limiting or curtailing ejaculation. Some Taoists go so far as to perform intercourse without any male completion whatsoever.

            With these in mind, one can’t help but notice the spiritually deadening effect of pornography, feminism and sleaze.

          • LHathaway

            Freud hinted at that as well (although to my limited knowledge he never came out and explicitly stated that). If we are motived by love or a sex drive, we have a limited or limiting amount of energy or motivation over the course of our live’s. He hinted that we should preserve this force in just such manner (if not in such an extreme way). Well, he just hinted at this, he didn’t propose a manner in which one would measure out one’s life or motivation.

          • David Ashton

            Freud penned some thoughtful essays but psycho-analysis is largely fraudulent.

        • andyrwebman

          To be honest, I think it’s being a victim of your own success and having it too comfortable – cheap energy, all the mod cons, high consumption. That combined with really mindless television.

          Oh, and allowing the feminists too much free reign, making men feel like useless appendages.

          • David Ashton

            Konrad Lorenz (1973) listed 8 deadly sins of “civilization” – overpopulation, environmental devastation, runaway technology that undermined human reflection, self-indulgent hedonism, genetic decay, rupture of inter-generational tradition, increased indoctrinability and WMD proliferation,

            He wrote: “The progress of technology and pharmacology furthers an increasing intolerance of everything inducing the least displeasure. Thus human beings lose the ability to experience a joy attainable only through surmounting serious obstacles. Natural waves of joy and sorrow ebb away into an imperceptible oscillation of unutterable boredom…. An individual who purposely keeps aloof from the influence of the mass media is regarded as pathological. Opinion polls, advertizing, cleverly directed fads and fashions help to attain power over the masses.”

            But wasn’t he a “Nazi” – like Martin Heidegger, Arnold Gehlen, Erwin Kolbenheyer, Carl Jung….?

      • adplatt126

        There is some sense in everything you say. But the whole “America is no 1” crap, that’s just pure drivel and always was.

        • Raymond Kidwell

          It’s weird that a nation of primarily retards could be number one in many measurements, although all of those measures are slipping now.

  • superlloyd

    Can it increase negro intelligence and all their other behavioural flaws? Not for a long time.

    • Anglokraut

      Do you really want something that aggressive to also be intelligent? We can barely hold a civilization that includes them, together, now!

      • TL2014

        Aggression can be addressed through hormonal therapy, I suppose.

    • Guy Luck

      Why would we want to bring them up to our level? That would only introduce more competitors on the world stage, the North East Asians and Jews are enough I think.

    • Tim_in_Indiana

      It could also be used for helping whites, such as by curing sterility and other problems.

      • Anglokraut

        I’ll bet there are a lot of White women out there who would like the chance to bear healthy children in their 40s and 50s, after they’ve had their “career”. I know I’d love to have that option.

    • Yves Vannes

      This therapy can erase the harmful mutation but it can’t “add” positive ones simply because they are all dispersed among several genes.

      Adding an intelligence gene to the Niger_Bantu would give us The Island of Dr. Moreau raised to an infinite power. They would use their new ability not to build but to prey upon what others have built. In other word, exactly what they are doing now except they’d be a lot more effective.

      • John Smith

        Proof is that the smartest negroes in Africa always take over and exploit all the dumbest ones, same as they do here.

      • Raymond Kidwell

        That description reminds me of —-. High I.Q.s directed at starting wars, bulldozing peoples homes, organized crimes, banking cartels and other activities that seem to cause innumerable unnecessary problems.

    • Max

      That would take a LOT of editing.

    • IBWHITE

      They would still be physically repulsive.

      • Reynardine

        At the end of the day, you realize “if we could improve black people, we’d practically make them white.” and then you realize there’s a much easier (and much more pleasurable) way to make white people.

    • Raymond Kidwell

      Blacks have been made less intelligent and more violent through our dysgenic programs. A lot of Africans from Africa are really docile (not all of them). American blacks are actually about the worst kind in the world. We created them. In the same way you’ll notice these giant muscle bound black people in America and go to Africa and they are all scrawny scare scrows (even when well fed) or else tiny pygmies. Well the slave breeders tried to create the biggest strongest slaves. If America can produce people like this, certainly it would be possible to reverse it and civilize a group.

  • I have a prediction that in the next 50 years the biggest conflict between traditional Christianity and mainstream society won’t involve gay marriage or abortion or school choice but rather the eugenics issue and the positive/negative change those technologies will bring.

    Q.

    • David Ashton

      Liberal and Christian opponents of HUMANITARIAN eugenic contraception or engineering share the Reductio ad Hitlerum.

    • adplatt126

      Sensible people have been fighting religious idiots for centuries.

  • MartelsGhost

    Any and all facets of this technology must be kept out of the hands of the rampaging libtards. They already are saying things like “only White babies are born racist” not a far reach to think some bright labcoat will suggest editing out certain qualities of White people to make them more “socially acceptable”.

    • Max

      Not needed. They are just editing white people out of existence.

  • Ultimate187

    Liberal Eugenics is a powerful frontier. Nothing else is capable of decreasing more crime, improving more health and instilling more potential. It is the premise of the movie Gattaca. There are many ethical considerations though, and any large scale application of these technologies would likely first happen outside Western nations, most likely in the Far East.

    • David Ashton

      Leftist biologists like Steve Jones take the view that now we can do it, we must not do it. The Chinese think otherwise.

  • TL2014

    You mean we can engineer Shitavia out of existence??

    Sounds too good to be true…

    • ghettovalley

      Thanks science!

    • Raymond Kidwell

      Insert a gene for black skin into your own genome. You’ll instantly become a genius. You’ll be on the cover of time magazine, given a free ride to harvard and probably have a highly successful political career. As soon as your skin turns white again, you’ll just be an average person and probably fired from your job and painted as a racist for all the politically popular remarks you made when black.

      • LHathaway

        Pretty funny. Good one.

  • John Smith

    Biological scientists are mostly leftists (and/or foreign and racial/ethnic minorities), so don’t expect this to work out positively for white people.

    • David Ashton

      This a remoter but realistic risk. Watch the journals. Julian Huxley, Teilhard de Chardin, Alexis Carrell and Raymond Cattell would have taken a different view.

  • Guy Luck

    Another way to get rid of their crime and illegitimacy is to sterilize them all or just shove them onto some sort of jungle reservation.

  • andyrwebman

    This is excellent news if we can get it to work in humans.

    It’s a method that shouldn’t offend the majority of pro-lifers – i.e. we’ll correct the genetic material before we even fertilise the egg. No need to do the IVF thing where you produce 6 embryos and check which ones are gnetically OK viable, binning the rest.

    The ideal situation woul be for people who were known carriers of e.g. Cyctic Fibrosis to have their genomes altered in a comparitively painless manner in Situ, so that evey sperm/egg produced form then on would be disease free.