Racial Difference in Blood Clotting Warrants a Closer Look at Heart Attack Medications

Medical Xpress, November 10, 2013

Thomas Jefferson University researchers have discovered that the formation of blood clots follows a different molecular route in African Americans versus European Americans, providing a new understanding of the effects of race on heart disease. The finding could one day help doctors provide more individualized treatment of heart disease and other blood-clot-related illnesses, according to research publishing online November 10th in Nature Medicine.

The finding may also provide an additional explanation for the disparity between outcomes in black and white patients with heart disease, which is the most common killer of white and black Americans. Compared to white patients, blacks have a two-fold increased incidence of heart disease and have a lower long-term survival. The reasons for this racial disparity are complex, and include racial bias, a higher prevalence of traditional risk factors in blacks, and differences in socioeconomic status, management and environment. However, even when these factors are considered, the survival of black heart attack patients is 2 and a half times lower than white patients. This suggests there are yet-to-be identified factors accounting for the racial disparity in heart disease.

“We may need to consider our patient’s race when using certain heart disease therapies,” said lead author of the research Paul Bray, M.D., Director of Thomas Jefferson University’s Cardeza Foundation for Hematologic Research.

Anti-platelet medications, such as aspirin, are commonly prescribed to prevent heart attack or stroke. These medications function by blocking the clot-forming activity of platelets—small cells that normally circulate in the blood stream and congeal around damaged or atherosclerotic blood vessels. The plaques in atherosclerotic vessels can occasionally rupture, causing the formation of a platelet plug that clogs blood vessels and can lead to heart attack or stroke. However, there is considerable variability in how patients respond to these medications, which confounds physicians who must deduce the appropriate drug and proper dose for each patient. Now, researchers from Thomas Jefferson University have identified some of the genetic differences behind these variations, which could help doctors treat racial groups with a more personalized and effective approach.

{snip}

Topics: , ,

Share This

We welcome comments that add information or perspective, and we encourage polite debate. If you log in with a social media account, your comment should appear immediately. If you prefer to remain anonymous, you may comment as a guest, using a name and an e-mail address of convenience. Your comment will be moderated.
  • Tarczan

    “However, even when these factors are considered, the survival of black heart attack patients is 2 and a half times lower than white patients.

    Not all the news is bad on the racial front these days.

    • Oil Can Harry

      How ironic that this discovery was made at a university named after the famed race realist Thomas Jefferson.

  • dd121

    Everyone knows we’re all exactly equal. These clotting differences are just another example of white privilege.

    • JohnEngelman

      Blood clotting is only a social construct.

      • IanJMacDonald

        Genes are racist. So are medical studies.

        • GOD

          Yup. Blood clotting is racist. Where’s Al?

  • DaveMed

    These racial disparities are present in almost every single area of medicine. It seems that only IQ and predisposition to violence are unaffected by genes…

    • M.

      The two most sensitive traits in a person’s behavior, what do you know! Nature is more politically correct than we thought.

    • Brian

      It’s funny how evolution stops at the neck like that.

  • JohnEngelman

    Liberals are willing to accept physical differences between the races. Nevertheless, they are unwilling to consider evidence for innate differences of ability levels and behavior.

    • Religious conservatives are also unwilling to accept that someone they think is “saved” because he can put up a good act, even though it might not in fact actually possess a soul.

      You hate “criminals”, but criminals are like Robert Heinlein’s cats after sunset. We are not all the same color, but of infinite variety.

  • APaige

    “In medicine, there is only one race—the human race.’’the New England Journal of Medicine, May 3, 2001.
    What you want to be true versus what is true.

    • haroldcrews

      That statement is a dogma of egalitarianism not science.

    • JohnEngelman

      If liberals really believed that they would not suppress a candid discussion of racial differences and the biological reasons for those differences.

  • Katherine McChesney

    ‘This suggests there are yet-to-be identified factors accounting for the racial disparity in heart disease.’

    Perhaps it’s simple. Could be that the black race is inferior to the other races of people. This could be the reason that they are such a failure in every aspect of life. Could also be the Curse of Ham.

    • M.

      If only natural selection were left to work its magic in Africa, without any of this white man’s aids interrupting it!
      But I think blacks do outdo other races in a few domains; namely, in bursts of strength, and in muscular predisposition to develop. Although whites beat them in muscular resistance.
      Blacks also outdo other races in skin thickness and average penis size. But that’s pretty much it.

      • ThatguyinTN

        Are you talking about american blacks or africans

        • M.

          Same thing. It’s the ancestry that matters, not their geographical location.

          • ThatguyinTN

            I agree its ancestry more than anything else but I think there is a distinct difference between africans and american blacks. From all the things I have ever seen about africa the africans don’t look any more muscular more well hung or anything above your average white. american blacks is another story and I think the difference is coming to an end. My thinking is that during the slave years in america when whites would buy blacks for studs they would pick the most well developed muscularly and otherwise and that would be the stud slave. After that we just bred them like cattle and if they were not physically superior in some way they were not bred. After all more physically fit means able to handle harder work. Since slavery ended they have been just breeding to breed and in my opinion are slowly working themselves back to the same physical nature of africans. So in essence any superior physical traits american blacks have is from their ancestors like you said but their ancestry was hand chosen at least in america by whites so we should be thanked by them for the athletic upper hand we gave them.

          • GOD

            Thankfully, the superior physical traits american blacks do have are usually supplemented with lots of unhealthy fast food. Thank you McDonalds. Keep up the good work.

      • Brian

        Resistance to malaria is another, and faster physical/motor development in infancy. Unfortunately none of their advantages are useful in building or sustaining modern civilization.

  • JDInSanD

    “We may need to consider our patient’s race.”

    Or they could just develop there own treatments. That will happen when pig valves fly.

    It’s funny how we’re constantly told that other cultures are just as good or superior to us but when it comes to our medicine or technology or wealth…well that all belongs to the world.

    • NordicHeritage

      Somebody call the splc “this be racist thinking”.

  • DailyKenn

    I’m old enough to remember when
    homosexuality was a social construct
    and race was genetic

    • Ted

      It is amazing how “schizophrene” campuses can get re all this. We can
      acknowledge genes “down there” but not “up here” And on the typical campus,
      the clothes hit the floor at the snap of fingers—a little kennel like. So pervert sex
      is gene real; straight sex is gene free. And tuition averages about $5k a semester.
      I need a double martini. Or a passport renewal!

  • Spartacus

    Race is not a social construct. Society is a racial construct.

  • ImTellinYa

    Blacks are a little vague about the consequences of their actions. They have poor impulse control. They are vastly more prone to self-destructive behavior. It is therefore probable that when a disproportionate number of them are recovering from a heart attack, they simply continue drinking, smoking and whatever else they do that is bad for them.

  • NordicHeritage

    But i thought race was just a social construct, that’s what the left keeps telling us.

  • George

    Mr. Taylor’s remarkable regard to these developments in science has provided in AR
    archives an overwhelming factual refutation to “race is but skin deep”. But I find that
    a surprising number of people, faced with such specific factual deflation of their views,
    will just ignore the unwelcome reality–such is the power of campus brainbathing these days.

    • I have read this irrefutable evidence described as “hate facts”. Even when they are forced to admit the truth, pulled bloody and screaming from them, the lefties still slander it as “hate”.

  • Stan D Mute

    Evil Rayciss doctors! Errybody know race be jus a soshal construck and dat it be only skin deep..

    Ergo, it is utterly impossible that there could be a difference on a cellular biological level.

  • it would be more productive to discuss why those at the top of society want to keep the white majority from thinking about racial differences, as opposed to focusing on the racial differences themselves.

  • ViktorNN

    Blood clots following a different molecular route in blacks than in whites is just a social construct.

  • RyanP

    The following decades are going to be very interesting. Science will continue to reveal the facts of racial diversity. At some point the “we are all the same” levee is going to break.

  • itdoesnotmatter

    As stated in the article right off the bat: “The reasons for this racial disparity are complex, and include racial bias……”
    Of course, that’s the number one reason. Why didn’t I think of that? [slaps forehead]

    • ThatguyinTN

      Heart attacks be rayciss yo!!!

  • Bossman

    This article is very vague and does not give any answers to the question of heart disease. From what I’ve read elsewhere is that Blacks have less clogged arteries but their kidneys are less capable of controlling blood volume especially under the influence of elements such as sodium, potassium, magnesium, etc.

  • WASP

    This is off the subject but speaking of racial differences, I’d like to know if any of you have seen the TV commercial with the White cowboy speaking in the supposed version of White ebonics(?). He’s completely unintelligible. I’ve never heard any White person from anywhere use such vernacular. It’s absurd. Another attempt now by liberals and MSM to put Whites in the same mode with Blacks.

    • ThatguyinTN

      I haven’t seen that one but speaking of commercials has anyone seen the racist KFC commercial? Its the one with the two cops, one white one black. White one shows up with a KFC go cup and they get a call. The black cop (apparently training the white cop) sends the white cop to do his job instead of going with to actually train him, and then while the white cop is gone the black cop steals his fried chicken. I mean come on how many black stereotypes can they touch on in one 30 second commercial.

      http://www(dot)youtube(dot)com/watch?v=EVv9HIP0jLQ

      • GOD

        I haven’t seen either one, but I’m getting pretty annoyed seeing that Geico tree-falling commercial over and over with the White woman & black “woman” on the treadmill. As always, the black is intelligent & the white is a dope. Too bad for the liberal media because real-life experiences are always standing in the way of their anti-White attempts.

        http://www(dot)youtube(dot)com/watch?v=6pW2bE61Z9U

  • ThatguyinTN

    Wouldn’t you be a world class runner if you spent all your time running from predatory animals (including their cousins)? But then maybe that is why the are genetically more athletic