Up to Eight Percent of South Asians Carry Gene Mutation That Causes Heart Attacks

Medical Xpress, January 15, 2015

Up to 8 percent of people from India, Pakistan, Bangladesh and other South Asian countries carry a mutated gene that causes heart failure and potentially fatal heart attacks.

A new study demonstrates how this gene mutation impairs the heart’s ability to pump blood. Results could point the way to eventual treatments and prevention strategies for an estimated 55 million people of South Asian descent worldwide, including 200,000 people in the United States, who carry the potentially fatal mutation.

The study, led by Sakthivel Sadayappan, PhD, MBA, of Loyola University Chicago Stritch School of Medicine, is published in the prestigious Journal of Biological Chemistry, a publication of the American Society for Biochemistry and Molecular Biology.

The mutation causes hypertrophic cardiomyopathy, the most common form of inherited cardiac disease and the leading cause of sudden cardiac death in young people. Previous studies by Dr. Sadayappan and other researchers have found that between 5 percent and 8 percent of South Asians carry the mutation. Carriers have about a 80 percent chance of developing heart failure after age 45. Dr. Sadayappan first reported the mutation in 2001 at the World Congress of the International Society for Heart Research, and has been studying it ever since. He said that, based on a report from one of his collaborators, the mutation likely arose in a single person roughly 33,000 to 55,000 years ago. The mutation then spread throughout South Asia.

The mutated gene encodes for a protein, called cardiac myosin binding protein-C (cMyBP-C), that controls cardiac muscle contractions and is critical for the normal functioning of the heart. In the mutated gene, 25 base pairs (DNA letters) are missing. As a result, the tail end of the protein is altered.

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  • HJ11

    Fewer non-White genes to compete with White genes.

    • LHathaway

      They will have born or sired their children well before succumbing to heart disease.

  • Oil Can Harry

    Yet another reason for whites not to engage in race mixing.

  • MekongDelta69

    I’m still waiting for Medical Xpress… Local to publish something about working a cure for diseases White people are prone to get.

    I’ll be right back… I’m gonna go wait over here… Wake me up when they do…

  • Easyrhino

    But, but but I thought we’re all the same with the only difference being skin color?

    • Earl P. Holt III

      Touche` !

  • anony

    Simply more proof that race is not a social construct. Who was the stupid Harvard professor pushing that tripe?

  • Reynardine

    And lo and behold, suddenly the Indian Caste system makes all the sense in the world…

  • KenelmDigby

    The evolutionary pressure on sub on Indians was to breed fast and die young.

  • IKUredux

    Are we paying for them? If not, I don’t care.

  • Ultimate187

    Even if they’re genetically predisposed to heart attacks, the main thing pushing them over the edge is still their cultural diet (rich in butter, oils and fats).