A high percentage of African-American women with breast cancer who were evaluated at a university cancer-risk clinic were found to carry inherited genetic mutations that increase their risk for breast cancer.

The finding suggests that inherited mutations may be more common than anticipated in this understudied group and may partially explain why African-Americans more often develop early onset and “triple-negative” breast cancer, an aggressive and difficult-to-treat form of the disease.

It also demonstrates the potential benefits of increased access to genetic counseling and testing for women with breast cancer and their close relatives. Through these services, family members who are found to share the same genetic risk factor for breast cancer can be offered personalized strategies for early detection and prevention of breast cancer.

“Our study confirms the importance of screening for mutations in breast cancer susceptibility genes in all African-American breast cancer patients diagnosed by age 45, those with a family history of breast or ovarian cancer, or with triple-negative breast cancer before age 60,” said study author Jane Churpek, MD, assistant professor of medicine at the University of Chicago Medicine.

{snip}

The study, to be presented June 3 at the 2013 Annual Meeting of the American Society of Clinical Oncology in Chicago, is the first comprehensive screening among African-American women of all 18 known breast cancer susceptibility genes using new methods called targeted genomic capture and next-generation sequencing. The researchers found that 56 of the 249 women studied (22 percent) at the University of Chicago Medicine’s Cancer Risk Clinic had inherited at least one damaging mutation that increased their risk of breast cancer. {snip}

{snip}

Whereas 12 percent of women in the general population will develop breast cancer by age 80, those carrying a harmful mutation in BRCA1 or BRCA2 have a 37 to 85 percent lifetime risk of developing breast cancer. Mutations in these genes provide the best tools for tailoring risk-reducing interventions.

The authors caution that the patients in this study are not a typical cross-section of African-American women. Two-thirds of them were referred to the cancer-risk clinic for genetic evaluation, often due to a family history of breast cancer. Not all of them, however, had this significant risk factor. Forty percent of the 249 patients had no family history of breast or ovarian cancer, yet the researchers found damaging mutations in 12 percent of those patients.

“We expected the women in our study to have a higher risk of carrying an inherited mutation than typical breast cancer patients,” Churpek said, “but some of their risk factors—diagnosis by age 45 or triple-negative breast cancer—also are more common among African-American women.”

Once diagnosed with breast cancer, African-American women have lower survival rates. Regional variations in survival suggest that much of the difference may be driven by reduced access to screening and optimal care, but there is mounting evidence, including this study, that differences in tumor biology, such as a higher rate of inherited mutations in genes that increase the risk of aggressive forms of breast cancer, also play a role. In those cases, delay of diagnosis can prove deadly.

{snip}

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  • bigone4u

    As these stories are put up on Amren, I gather that genetics may offer an argument against miscegenation. If I a white man were to marry and breed with a black woman, not only would I be cursed with children who do not look like me, but also my daughters might be carriers of genes that predispose blacks to breast cancer and sickle cell anemia, along with whatever else is found by scientists. Maybe I’m wrong, but scientifically it appears that there may be good reasons to mate within the race if your race is caucasian.

    • The__Bobster

      You would also have offspring that would be hard to match for organ donations.

    • AllSeeingEyeSpy

      I think Blacks are more prone to Glaucoma also. It might be a reason they’d want to date with you.

      • bigone4u

        Yes, compared to a black man I am easy to find in the dark.

      • Bossman

        That is not what I read. Glaucoma is highest among white people with blue eyes and less common among dark-eyed people.

    • Bossman

      Breast cancer is highest among white women of Northern European ancestry and lowest among East Asian women. That has been the official statistics for some time now.

    • Elli

      OTOH, your children would be less likely to get skin cancer, cystic fibrosis, hemachromatosis or Huntington’s disease.

      • Bon, From the Land of Babble

        Not one of the reasons you listed is justification for Whites breeding with non-Whites. We are a global minority under threat of genocide and have every right to preserve our unique DNA — along with our culture, heritage, language and, especially our homelands.

        NOTHING justifies the genocide of the White race.

        Bon

      • anonymous_amren

        Also, they would get the chance to appear in Cheerios commercials.

        • Brenda

          You really should not make light of such a devastating disease!

  • The__Bobster

    The finding suggests that inherited mutations may be more common than anticipated in this understudied group and may partially explain why African-Americans more often develop early onset and “triple-negative” breast cancer, an aggressive and difficult-to-treat form of the disease.
    ___________

    Odd that the libtards in the MSM haven’t been beating their drums about this “epidemic”.

    • bigone4u

      There will soon be a telethon to raise money for the poor victims of this dreaded genetic condition. Hosted by Jamie Foxx perhaps.

    • Bossman

      Haiti was recently listed as the country with the lowest rate of breast cancer in the whole world.

      • QuinnTheEskimo9

        Prove it. Let’s see the data on that.

      • anonymous_amren

        That makes sense if people die young there, or if people are malnourished. But it’s probably not even measured, so we wouldn’t know the real rate.

        • Bossman

          That is correct. They don’t have good statistics. Other people suggest that diet and climate should be taken into account as variables affecting this disease. Vitamin D from sunlight, low fat diets could be important variables.

  • MikeS

    “Genes help explain blacks’ higher risk for breast cancer and lower survival rates”
    As well as their lower overall intelligence and non-civilized behavior.

    • Bossman

      That is not really true. What I’ve read in the past is that breast cancer is highest among white women of northern European ancestry and lowest among East Asian women. When Blacks get it, it is of the more aggressive kind. Black women in Africa and Haiti have very low rates of breast cancer.. In fact, Haiti was recently listed as the country with the lowest rate of breast cancer in the whole wide world.

      • Bon, From the Land of Babble

        Put up a link.

        • Bossman

          No! I don’t have to put up a link. If you think that the data is wrong, it’s up to you to prove that I’m wrong.

          • Bon, From the Land of Babble

            You’re the one making the silly assertion, not me — it’s up to you to prove it.
            But then you try to pass off a lot of your childish OPINIONS as fact, LOL.

            And, your OPINION is wrong until you prove it.

          • QuinnTheEskimo9

            Bon: Bossman has a habit of doing this, posting the marxist pap that his cult handlers have fed him to “fight evil white supremacists” as if it is fact and devine truth. He never backs up what he writes.

            He’s drunk the marxist Kool Aid straight from the toilet bowl. Maybe he’ll get better and join reality at some point…but maybe not.

            Until then, don’t feed the troll.

          • Bossman

            You’ve got it ass-backwards. The one making the assertion does not have to prove anything, It is up to the challenger to prove him wrong.

          • anonymous_amren

            The correctness of opinions is fixed beforehand, it doesn’t change just because you haven’t heard his proof. You could Google it yourself and check whether it is right or wrong.

          • QuinnTheEskimo9

            I’d also like to see the research and statistics to back up what you’re posting instead of deflection, “prove that I’m wrong.”

            Why the childish reply, “Bossman?” You’ve got to knock it off. Why can’t you reply properly? Your response is with nothing more than a childish answer, without actually backing-up, presenting facts or having any points but deflection..

          • anonymous_amren

            Boss man is right. According to RG Fruchter et all, 1990, Haitians do have a lower incidence of breast cancer. I’m not sure how reliable the methodology is though.

            He’s also right that he doesn’t have to do our googling for us.

          • Bossman

            Thank you for backing me up.

  • So CAL Snowman

    Great in addition to treating them for sickle cell anemia, we know have to treat them for higher rates of cancer incidence. Blacks, the gift that keeps on giving.

    • MAX

      I would not wish cancer on anyone ….no matter what color…

      • Nancy

        I agree. As someone who lost their mother form breast cancer (I am White) when I was 16, she was 44, I can attest to the fact that it is a terrible disease that I would not wish upon anyone.

        • Gregory

          Indeed.

  • APaige

    Dem jean mule tashons b raciss

  • IKantunderstand

    Not sure why this article was even posted here. What’s up, Amren? Got the hots for Hottentots?

    • Elli

      The point being that science accepts that there are genetic differences between races that are more than “skin deep” when it comes to disease. Perhaps it will some day be acceptable to research other genetic differences.

    • Nowayinhell Amigivingyoumyname

      It makes total sense as to why this was posted here. IN the universites, sandwiched in between liberal rantfests claiming “race doesn’t even exist, biologists know this isn’t true” are little nuggets of information that shine through such as the realization that SIDS has an incidence many times higher among black children, even when all other factors are equal. That’s right – among middle class, non-smoking, healthy young women, the black child will simply die unexplainedly 3-4 times more often than the white child. This is called a genetic difference, and cannot be explained away by liberal blathering.
      Where one genetic difference exists, more exist.

  • AllSeeingEyeSpy

    Black women are more likely to be poor? Poor and alone? They are more likely to be exposed to pollution, both at home and at work. And perhaps they’ve had more X-rays and CAT scans over their lifetimes. Both would contribute to higher rates of cancer.

    • Bossman

      None of this is making any sense to me. Not too long ago I saw a statistics which said that Haiti has the lowest rate of breast cancer in the whole wide world.

      • QuinnTheEskimo9

        “None of this is making any sense.”

        Then you need to stop posting now before making a fool of yourself as you do downthread.

        • Bossman

          No! I’m not making a fool of myself, the statistics still stand, white women of Northern European ancestry have the highest incidence of the disease and East Asian women the lowest.

          • QuinnTheEskimo9

            What statistics? None exist, you’re just making them up and faking it as any sociopath would.

  • Bossman

    Not too long ago the medical people were saying that breast cancer was highest among white women of northern European ancestry. There was also a statistic which said that breast cancer was very high among lesbians. Are they really sure?

    • Elli

      Higher incidence among white women, more likely fatal in black women. Higher incidence in women who have their first child at an older age, who abort their first pregnancy, who have few or no children, who do not breast feed.

      So lesbians or nuns for that matter would be at higher risk.

    • QuinnTheEskimo9

      How about looking it up instead of asking “Are they really sure?”

      How about doing a little research first before running your keyboard before engaging your brain.

  • Alexandra1973

    I’d think that diet would be a factor too.

  • Bon, From the Land of Babble

    Another article about black issues? WHY? I don’t come here to read about blacks and their health, etc.

    Let blacks worry about it, we Whites have enough issues, like say — the genocide that is being conducted against us in our homelands.

    Blacks and breast cancer?

    I Don’t Give A Rat’s A**

    Bon

    • QuinnTheEskimo9

      I’ll second that.

      • anonymous_amren

        Knowing that black people are genetically different is WHY I care about race replacement in the west. Jared Taylor knows what he’s doing.