DNA Mutation Boosts Heart Disease Risk In Whites

Reuters, May 4, 2007

A treasure hunt for genes has found that up to three-quarters of people of European descent have DNA that raises their risk for heart disease—and these genes are close to a stretch of DNA linked to diabetes.

The findings, made by two independent groups of researchers, may help explain why so many people have heart disease even if they do not have clear risk factors such as smoking, high cholesterol or high blood pressure.

And they could lead to a test to predict the risk of heart disease, the biggest cause of death across the globe.

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Both teams used a new method of combing the genome for disease genes called a genome-wide association study, which was not possible until the full human genome was published in 2003. Now scientists can map the DNA of people with a disease, compare them to this template genome or to people without a disease, and find what is different.

The two studies, using 40,000 people, found the same thing—a stretch of DNA called 9q21 carried certain mutations in people with heart disease. It is an area that had not previously been identified as a gene, which may make it more difficult to determine how it causes disease, scientists said.

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Heart attack risk

The deCODE team found that about 21 percent of the people they tested had mutations in both copies of this DNA stretch, giving them a 64 percent higher risk of a heart attack than people who carried no copies of the mutation.

McPherson’s team said 20 to 25 percent of Caucasians they tested carrying two mutated copies of 9q21 and had a 30 to 40 percent higher risk of coronary heart disease than people without the mutation. Half the people had one copy and they had a 15 percent to 20 percent higher risk of heart disease.

Africans did not appear to carry the mutations, and in African-Americans, the mutations were not associated with heart disease risk, McPherson’s team wrote.

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